LrgpV1, Main, Exploration, bibRecord, 000008

Production of singlet Oxygen by nanoparticle-bound photosensitizers

Identifieur interne : 000008 ( Main/Exploration ); précédent : 000007; suivant : 000009

Production of singlet Oxygen by nanoparticle-bound photosensitizers

Auteurs : Aurélie Stallivieri [France] ; Francis Baros [France] ; Philippe Arnoux [France] ; Régis Vanderesse [France] ; Muriel Barberi-Heyob [France] ; Céline Frochot [France]

Source :

RBID : Hal:hal-01288737

Abstract

New improvements in the field of targeted PDT concern the use of nanoparticles that can serve as carriers for anticancer agent delivery. Nanoparticles do indeed offer many advantages such as good colloidal stability, effective protection of encapsulated drugs against enzymes and hydrolysis, surface tailor ability and multipurpose, and easy, synthesis. More importantly, thanks to their size, nanoparticles are a means to allow selective accumulation of the PS in cancer cells due to the enhanced permeability and retention effect of tumor tissues. In this chapter, we will focus on the production of singlet oxygen (1O2*) after excitation of PS coupled or encapsulated into nanoparticles possessing a three-dimensional rigid matrix. We define three types of nano-objects: nanoparticles in which the ΦΔ of photosensitizers increases compared to free photosensitizers, nanoparticles in which the ΦΔ of the encapsulated PS decreases compared to ΦΔ of the free photosensitizer and systems in which ΦΔ of the encapsulated or free PS are similar.

Url:

https://hal.archives-ouvertes.fr/hal-01288737

DOI: 10.1039/9781782622208-00209

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000943
to stream Hal, to step Curation: 000943
to stream Hal, to step Checkpoint: 000009
to stream Main, to step Merge: 000008
to stream Main, to step Curation: 000008

Le document en format XML

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<idno type="DOI">10.1039/9781782622208-00209</idno>
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<front><div type="abstract" xml:lang="en">New improvements in the field of targeted PDT concern the use of nanoparticles that can serve as carriers for anticancer agent delivery. Nanoparticles do indeed offer many advantages such as good colloidal stability, effective protection of encapsulated drugs against enzymes and hydrolysis, surface tailor ability and multipurpose, and easy, synthesis. More importantly, thanks to their size, nanoparticles are a means to allow selective accumulation of the PS in cancer cells due to the enhanced permeability and retention effect of tumor tissues. In this chapter, we will focus on the production of singlet oxygen (1O2*) after excitation of PS coupled or encapsulated into nanoparticles possessing a three-dimensional rigid matrix. We define three types of nano-objects: nanoparticles in which the ΦΔ of photosensitizers increases compared to free photosensitizers, nanoparticles in which the ΦΔ of the encapsulated PS decreases compared to ΦΔ of the free photosensitizer and systems in which ΦΔ of the encapsulated or free PS are similar.</div>
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<tree><country name="France"><region name="Grand Est"><name sortKey="Stallivieri, Aurelie" sort="Stallivieri, Aurelie" uniqKey="Stallivieri A" first="Aurélie" last="Stallivieri">Aurélie Stallivieri</name>
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Production of singlet Oxygen by nanoparticle-bound photosensitizers

Production of singlet Oxygen by nanoparticle-bound photosensitizers

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